Contact Force Analysis in Static Two-fingered Robot Grasping

[[abstract]]Static grasping of a spherical object by two robot fingers is studied in this paper. The fingers may be rigid bodies or elastic beams, they may grasp the body with various orientation angles, and the tightening displacements may be linear or angular. Closed-form solutions for normal and tangential contact forces due to tightening displacements are obtained by solving compatibility equations, force-displacement relations based on Hertz contact theory, and equations of equilibrium. Solutions show that relations between contact forces and tightening displacements depend upon the orientation of the fingers, the elastic constants of the materials, and area moments of inertia of the beams.[[sponsorship]]American Society of Mechanical Engineers[[notice]]補正完成[[incitationindex]]EI[[conferencetype]]國際[[conferencedate]]20130804~20130807[[booktype]]電子版[[iscallforpapers]]Y[[conferencelocation]]Portland, Oregon, US

A multimodal cell census and atlas of the mammalian primary motor cortex

ABSTRACT We report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties, and cellular resolution input-output mapping, integrated through cross-modal computational analysis. Together, our results advance the collective knowledge and understanding of brain cell type organization: First, our study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a unified taxonomy of transcriptomic types and their hierarchical organization that are conserved from mouse to marmoset and human. Third, cross-modal analysis provides compelling evidence for the epigenomic, transcriptomic, and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types and subtypes. Fourth, in situ single-cell transcriptomics provides a spatially-resolved cell type atlas of the motor cortex. Fifth, integrated transcriptomic, epigenomic and anatomical analyses reveal the correspondence between neural circuits and transcriptomic cell types. We further present an extensive genetic toolset for targeting and fate mapping glutamatergic projection neuron types toward linking their developmental trajectory to their circuit function. Together, our results establish a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties

Graphical Analysis for Locating Direct Singular Positions of the Parallel Manipulator MIPS

[[abstract]]It is shown in this study the graphical analysis using velocity polygons may be used to locate direct singular positions of a limited degree-of-freedom (DOF) parallel manipulator. The three DOF parallel manipulator MIPS is treated for illustration. The conditions for the moving platform to become movable under zero driving speeds can be obtained using the graphical velocity analysis. Manipulator configurations satisfying these conditions are direct singular positions. Several direct singular positions are determined using this technique. In order to verify these singular positions, Jacobian matrix for this manipulator is also derived in this study, and singular positions determined from graphical analysis can make the Jacobian matrix singular.[[notice]]補正完畢[[journaltype]]國外[[incitationindex]]SCI[[incitationindex]]EI[[booktype]]紙

Search for anomaly-mediated supersymmetry breaking with the ATLAS detector based on a disappearing-track signature in pp collisions at sqrt(s) = 7TeV$

none3019G. Aad;B. Abbott;J. Abdallah;A. A. Abdelalim;A. Abdesselam;O. Abdinov;B. Abi;M. Abolins;H. Abramowicz;H. Abreu;E. Acerbi;B. S. Acharya;D. L. Adams;T. N. Addy;J. Adelman;M. Aderholz;S. Adomeit;P. Adragna;T. Adye;S. Aefsky;J. A. Aguilar-Saavedra;M. Aharrouche;S. P. Ahlen;F. Ahles;A. Ahmad;M. Ahsan;G. Aielli;T. Akdogan;T. P. A. Åkesson;G. Akimoto;A. V. Akimov;A. Akiyama;M. S. Alam;M. A. Alam;J. Albert;S. Albrand;M. Aleksa;I. N. Aleksandrov;F. Alessandria;C. Alexa;G. Alexander;G. Alexandre;T. Alexopoulos;M. Alhroob;M. Aliev;G. Alimonti;J. Alison;M. Aliyev;P. P. Allport;S. E. Allwood-Spiers;J. Almond;A. Aloisio;R. Alon;A. Alonso;B. Alvarez Gonzalez;M. G. Alviggi;K. Amako;P. Amaral;C. Amelung;V. V. Ammosov;A. Amorim;G. Amorós;N. Amram;C. Anastopoulos;L. S. Ancu;N. Andari;T. Andeen;C. F. Anders;G. Anders;K. J. Anderson;A. Andreazza;V. Andrei;M-L. Andrieux;X. S. Anduaga;A. Angerami;F. Anghinolfi;A. Anisenkov;N. Anjos;A. Annovi;A. Antonaki;M. Antonelli;A. Antonov;J. Antos;F. Anulli;S. Aoun;L. Aperio Bella;R. Apolle;G. Arabidze;I. Aracena;Y. Arai;A. T. H. Arce;J. P. Archambault;S. Arfaoui;J-F. Arguin;E. Arik;M. Arik;A. J. Armbruster;O. Arnaez;C. Arnault;A. Artamonov;G. Artoni;D. Arutinov;S. Asai;R. Asfandiyarov;S. Ask;B. Åsman;L. Asquith;K. Assamagan;A. Astbury;A. Astvatsatourov;B. Aubert;E. Auge;K. Augsten;M. Aurousseau;G. Avolio;R. Avramidou;D. Axen;C. Ay;G. Azuelos;Y. Azuma;M. A. Baak;G. Baccaglioni;C. Bacci;A. M. Bach;H. Bachacou;K. Bachas;G. Bachy;M. Backes;M. Backhaus;E. Badescu;P. Bagnaia;S. Bahinipati;Y. Bai;D. C. Bailey;T. Bain;J. T. Baines;O. K. Baker;M. D. Baker;S. Baker;E. Banas;P. Banerjee;Sw. Banerjee;D. Banfi;A. Bangert;V. Bansal;H. S. Bansil;L. Barak;S. P. Baranov;A. Barashkou;A. Barbaro Galtieri;T. Barber;E. L. Barberio;D. Barberis;M. Barbero;D. Y. Bardin;T. Barillari;M. Barisonzi;T. Barklow;N. Barlow;B. M. Barnett;R. M. Barnett;A. Baroncelli;G. Barone;A. J. Barr;F. Barreiro;J. Barreiro Guimarães da Costa;P. Barrillon;R. Bartoldus;A. E. Barton;V. Bartsch;R. L. Bates;L. Batkova;J. R. Batley;A. Battaglia;M. Battistin;G. Battistoni;F. Bauer;H. S. Bawa;S. Beale;B. Beare;T. Beau;P. H. Beauchemin;R. Beccherle;P. Bechtle;H. P. Beck;S. Becker;M. Beckingham;K. H. Becks;A. J. Beddall;A. Beddall;S. Bedikian;V. A. Bednyakov;C. P. Bee;M. Begel;S. Behar Harpaz;P. K. Behera;M. Beimforde;C. Belanger-Champagne;P. J. Bell;W. H. Bell;G. Bella;L. Bellagamba;F. Bellina;M. Bellomo;A. Belloni;O. Beloborodova;K. Belotskiy;O. Beltramello;S. Ben Ami;O. Benary;D. Benchekroun;C. Benchouk;M. Bendel;N. Benekos;Y. Benhammou;J. A. Benitez Garcia;D. P. Benjamin;M. Benoit;J. R. Bensinger;K. Benslama;S. Bentvelsen;D. Berge;E. Bergeaas Kuutmann;N. Berger;F. Berghaus;E. Berglund;J. Beringer;P. Bernat;R. Bernhard;C. Bernius;T. Berry;C. Bertella;A. Bertin;F. Bertinelli;F. Bertolucci;M. I. Besana;N. Besson;S. Bethke;W. Bhimji;R. M. Bianchi;M. Bianco;O. Biebel;S. P. Bieniek;K. Bierwagen;J. Biesiada;M. Biglietti;H. Bilokon;M. Bindi;S. Binet;A. Bingul;C. Bini;C. Biscarat;U. Bitenc;K. M. Black;R. E. Blair;J.-B. Blanchard;G. Blanchot;T. Blazek;C. Blocker;J. Blocki;A. Blondel;W. Blum;U. Blumenschein;G. J. Bobbink;V. B. Bobrovnikov;S. S. Bocchetta;A. Bocci;C. R. Boddy;M. Boehler;J. Boek;N. Boelaert;S. Böser;J. A. Bogaerts;A. Bogdanchikov;A. Bogouch;C. Bohm;V. Boisvert;T. Bold;V. Boldea;N. M. Bolnet;M. Bona;V. G. Bondarenko;M. Bondioli;M. Boonekamp;G. Boorman;C. N. Booth;S. Bordoni;C. Borer;A. Borisov;G. Borissov;I. Borjanovic;S. Borroni;K. Bos;D. Boscherini;M. Bosman;H. Boterenbrood;D. Botterill;J. Bouchami;J. Boudreau;E. V. Bouhova-Thacker;C. Bourdarios;N. Bousson;A. Boveia;J. Boyd;I. R. Boyko;N. I. Bozhko;I. Bozovic-Jelisavcic;J. Bracinik;A. Braem;P. Branchini;G. W. Brandenburg;A. Brandt;G. Brandt;O. Brandt;U. Bratzler;B. Brau;J. E. Brau;H. M. Braun;B. Brelier;J. Bremer;R. Brenner;S. Bressler;D. Breton;D. Britton;F. M. Brochu;I. Brock;R. Brock;T. J. Brodbeck;E. Brodet;F. Broggi;C. Bromberg;J. Bronner;G. Brooijmans;W. K. Brooks;G. Brown;H. Brown;P. A. Bruckman de Renstrom;D. Bruncko;R. Bruneliere;S. Brunet;A. Bruni;G. Bruni;M. Bruschi;T. Buanes;Q. Buat;F. Bucci;J. Buchanan;N. J. Buchanan;P. Buchholz;R. M. Buckingham;A. G. Buckley;S. I. Buda;I. A. Budagov;B. Budick;V. Büscher;L. Bugge;D. Buira-Clark;O. Bulekov;M. Bunse;T. Buran;H. Burckhart;S. Burdin;T. Burgess;S. Burke;E. Busato;P. Bussey;C. P. Buszello;F. Butin;B. Butler;J. M. Butler;C. M. Buttar;J. M. Butterworth;W. Buttinger;S. Cabrera Urbán;D. Caforio;O. Cakir;P. Calafiura;G. Calderini;P. Calfayan;R. Calkins;L. P. Caloba;R. Caloi;D. Calvet;S. Calvet;R. Camacho Toro;P. Camarri;M. Cambiaghi;D. Cameron;L. M. Caminada;S. Campana;M. Campanelli;V. Canale;F. Canelli;A. Canepa;J. Cantero;L. Capasso;M. D. M. Capeans Garrido;I. Caprini;M. Caprini;D. Capriotti;M. Capua;R. Caputo;C. Caramarcu;R. Cardarelli;T. Carli;G. Carlino;L. Carminati;B. Caron;S. Caron;G. D. Carrillo Montoya;A. A. Carter;J. R. Carter;J. Carvalho;D. Casadei;M. P. Casado;M. Cascella;C. Caso;A. M. Castaneda Hernandez;E. Castaneda-Miranda;V. Castillo Gimenez;N. F. Castro;G. Cataldi;F. Cataneo;A. Catinaccio;J. R. Catmore;A. Cattai;G. Cattani;S. Caughron;D. Cauz;P. Cavalleri;D. Cavalli;M. Cavalli-Sforza;V. Cavasinni;F. Ceradini;A. S. Cerqueira;A. Cerri;L. Cerrito;F. Cerutti;S. A. Cetin;F. Cevenini;A. Chafaq;D. Chakraborty;K. Chan;B. Chapleau;J. D. Chapman;J. W. Chapman;E. Chareyre;D. G. Charlton;V. Chavda;C. A. Chavez Barajas;S. Cheatham;S. Chekanov;S. V. Chekulaev;G. A. Chelkov;M. A. Chelstowska;C. Chen;H. Chen;S. Chen;T. Chen;X. Chen;S. Cheng;A. Cheplakov;V. F. Chepurnov;R. Cherkaoui El Moursli;V. Chernyatin;E. Cheu;S. L. Cheung;L. Chevalier;G. Chiefari;L. Chikovani;J. T. Childers;A. Chilingarov;G. Chiodini;M. V. Chizhov;G. Choudalakis;S. Chouridou;I. A. Christidi;A. Christov;D. Chromek-Burckhart;M. L. Chu;J. Chudoba;G. Ciapetti;K. Ciba;A. K. Ciftci;R. Ciftci;D. Cinca;V. Cindro;M. D. Ciobotaru;C. Ciocca;A. Ciocio;M. Cirilli;M. Citterio;M. Ciubancan;A. Clark;P. J. Clark;W. Cleland;J. C. Clemens;B. Clement;C. Clement;R. W. Clifft;Y. Coadou;M. Cobal;A. Coccaro;J. Cochran;P. Coe;J. G. Cogan;J. Coggeshall;E. Cogneras;C. D. Cojocaru;J. Colas;A. P. Colijn;N. J. Collins;C. Collins-Tooth;J. Collot;G. Colon;P. Conde Muiño;E. Coniavitis;M. C. Conidi;M. Consonni;V. Consorti;S. Constantinescu;C. Conta;F. Conventi;J. Cook;M. Cooke;B. D. Cooper;A. M. Cooper-Sarkar;K. Copic;T. Cornelissen;M. Corradi;F. Corriveau;A. Cortes-Gonzalez;G. Cortiana;G. Costa;M. J. Costa;D. Costanzo;T. Costin;D. Côté;R. Coura Torres;L. Courneyea;G. Cowan;C. Cowden;B. E. Cox;K. Cranmer;F. Crescioli;M. Cristinziani;G. Crosetti;R. Crupi;S. Crépé-Renaudin;C.-M. Cuciuc;C. Cuenca Almenar;T. Cuhadar Donszelmann;M. Curatolo;C. J. Curtis;C. Cuthbert;P. Cwetanski;H. Czirr;Z. Czyczula;S. D’Auria;M. D’Onofrio;A. D’Orazio;P. V. M. Silva;C. Via;W. Dabrowski;T. Dai;C. Dallapiccola;M. Dam;M. Dameri;D. S. Damiani;H. O. Danielsson;D. Dannheim;V. Dao;G. Darbo;G. L. Darlea;C. Daum;W. Davey;T. Davidek;N. Davidson;R. Davidson;E. Davies;M. Davies;A. R. Davison;Y. Davygora;E. Dawe;I. Dawson;J. W. Dawson;R. K. Daya-Ishmukhametova;K. De;R. Asmundis;S. Castro;P. E. Castro Faria Salgado;S. Cecco;J. Graat;N. Groot;P. Jong;C. Taille;H. Torre;B. Lotto;L. Mora;L. Nooij;D. Pedis;A. Salvo;U. Sanctis;A. Santo;J. B. Vivie De Regie;S. Dean;W. J. Dearnaley;R. Debbe;C. Debenedetti;D. V. Dedovich;J. Degenhardt;M. Dehchar;C. Papa;J. Peso;T. Prete;T. Delemontex;M. Deliyergiyev;A. Dell’Acqua;L. Dell’Asta;M. Pietra;D. Volpe;M. Delmastro;N. Delruelle;P. A. Delsart;C. Deluca;S. Demers;M. Demichev;B. Demirkoz;J. Deng;S. P. Denisov;D. Derendarz;J. E. Derkaoui;F. Derue;P. Dervan;K. Desch;E. Devetak;P. O. Deviveiros;A. Dewhurst;B. DeWilde;S. Dhaliwal;R. Dhullipudi;A. Ciaccio;L. Ciaccio;A. Girolamo;B. Girolamo;S. Luise;A. Mattia;B. Micco;R. Nardo;A. Simone;R. Sipio;M. A. Diaz;F. Diblen;E. B. Diehl;J. Dietrich;T. A. Dietzsch;S. Diglio;K. Dindar Yagci;J. Dingfelder;C. Dionisi;P. Dita;S. Dita;F. Dittus;F. Djama;T. Djobava;M. A. B. Vale;A. Valle Wemans;T. K. O. Doan;M. Dobbs;R. Dobinson;D. Dobos;E. Dobson;J. Dodd;C. Doglioni;T. Doherty;Y. Doi;J. Dolejsi;I. Dolenc;Z. Dolezal;B. A. Dolgoshein;T. Dohmae;M. Donadelli;M. Donega;J. Donini;J. Dopke;A. Doria;A. Anjos;M. Dosil;A. Dotti;M. T. Dova;J. D. Dowell;A. D. Doxiadis;A. T. Doyle;Z. Drasal;J. Drees;N. Dressnandt;H. Drevermann;C. Driouichi;M. Dris;J. Dubbert;S. Dube;E. Duchovni;G. Duckeck;A. Dudarev;F. Dudziak;M. Dührssen;I. P. Duerdoth;L. Duflot;M-A. Dufour;M. Dunford;H. Duran Yildiz;R. Duxfield;M. Dwuznik;F. Dydak;M. Düren;W. L. Ebenstein;J. Ebke;S. Eckweiler;K. Edmonds;C. A. Edwards;N. C. Edwards;W. Ehrenfeld;T. Ehrich;T. Eifert;G. Eigen;K. Einsweiler;E. Eisenhandler;T. Ekelof;M. Kacimi;M. Ellert;S. Elles;F. Ellinghaus;K. Ellis;N. Ellis;J. Elmsheuser;M. Elsing;D. Emeliyanov;R. Engelmann;A. Engl;B. Epp;A. Eppig;J. Erdmann;A. Ereditato;D. Eriksson;J. Ernst;M. Ernst;J. Ernwein;D. Errede;S. Errede;E. Ertel;M. Escalier;C. Escobar;X. Espinal Curull;B. Esposito;F. Etienne;A. I. Etienvre;E. Etzion;D. Evangelakou;H. Evans;L. Fabbri;C. Fabre;R. M. Fakhrutdinov;S. Falciano;Y. Fang;M. Fanti;A. Farbin;A. Farilla;J. Farley;T. Farooque;S. M. Farrington;P. Farthouat;P. Fassnacht;D. Fassouliotis;B. Fatholahzadeh;A. Favareto;L. Fayard;S. Fazio;R. Febbraro;P. Federic;O. L. Fedin;W. Fedorko;M. Fehling-Kaschek;L. Feligioni;D. Fellmann;C. Feng;E. J. Feng;A. B. Fenyuk;J. Ferencei;J. Ferland;W. Fernando;S. Ferrag;J. Ferrando;V. Ferrara;A. Ferrari;P. Ferrari;R. Ferrari;A. Ferrer;M. L. Ferrer;D. Ferrere;C. Ferretti;A. Ferretto Parodi;M. Fiascaris;F. Fiedler;A. Filipčič;A. Filippas;F. Filthaut;M. Fincke-Keeler;M. C. N. Fiolhais;L. Fiorini;A. Firan;G. Fischer;P. Fischer;M. J. Fisher;M. Flechl;I. Fleck;J. Fleckner;P. Fleischmann;S. Fleischmann;T. Flick;L. R. Flores Castillo;M. J. Flowerdew;M. Fokitis;T. Fonseca Martin;J. Fopma;D. A. Forbush;A. Formica;A. Forti;D. Fortin;J. M. Foster;D. Fournier;A. Foussat;A. J. Fowler;K. Fowler;H. Fox;P. Francavilla;S. Franchino;D. Francis;T. Frank;M. Franklin;S. Franz;M. Fraternali;S. Fratina;S. T. French;F. Friedrich;R. Froeschl;D. Froidevaux;J. A. Frost;C. Fukunaga;E. Fullana Torregrosa;J. Fuster;C. Gabaldon;O. Gabizon;T. Gadfort;S. Gadomski;G. Gagliardi;P. Gagnon;C. Galea;E. J. Gallas;V. Gallo;B. J. Gallop;P. Gallus;K. K. Gan;Y. S. Gao;V. A. Gapienko;A. Gaponenko;F. Garberson;M. Garcia-Sciveres;C. García;J. E. García Navarro;R. W. Gardner;N. Garelli;H. Garitaonandia;V. Garonne;J. Garvey;C. Gatti;G. Gaudio;O. Gaumer;B. Gaur;L. Gauthier;I. L. Gavrilenko;C. Gay;G. Gaycken;J-C. Gayde;E. N. Gazis;P. Ge;C. N. P. Gee;D. A. A. Geerts;Ch. Geich-Gimbel;K. Gellerstedt;C. Gemme;A. Gemmell;M. H. Genest;S. Gentile;M. George;S. George;P. Gerlach;A. Gershon;C. Geweniger;H. Ghazlane;N. Ghodbane;B. Giacobbe;S. Giagu;V. Giakoumopoulou;V. Giangiobbe;F. Gianotti;B. Gibbard;A. Gibson;S. M. Gibson;L. M. Gilbert;V. Gilewsky;D. Gillberg;A. R. Gillman;D. M. Gingrich;J. Ginzburg;N. Giokaris;M. P. Giordani;R. Giordano;F. M. Giorgi;P. Giovannini;P. F. Giraud;D. Giugni;M. Giunta;P. Giusti;B. K. Gjelsten;L. K. Gladilin;C. Glasman;J. Glatzer;A. Glazov;K. W. Glitza;G. L. Glonti;J. Godfrey;J. Godlewski;M. Goebel;T. Göpfert;C. Goeringer;C. Gössling;T. Göttfert;S. Goldfarb;T. Golling;S. N. Golovnia;A. Gomes;L. S. Gomez Fajardo;R. Gonçalo;J. Goncalves Pinto Firmino Da Costa;L. Gonella;A. Gonidec;S. Gonzalez;S. González de la Hoz;G. Gonzalez Parra;M. L. Gonzalez Silva;S. Gonzalez-Sevilla;J. J. Goodson;L. Goossens;P. A. Gorbounov;H. A. Gordon;I. Gorelov;G. Gorfine;B. Gorini;E. Gorini;A. Gorišek;E. Gornicki;S. A. Gorokhov;V. N. Goryachev;B. Gosdzik;M. Gosselink;M. I. Gostkin;I. Gough Eschrich;M. Gouighri;D. Goujdami;M. P. Goulette;A. G. Goussiou;C. Goy;S. Gozpinar;I. Grabowska-Bold;P. Grafström;K-J. Grahn;F. Grancagnolo;S. Grancagnolo;V. Grassi;V. Gratchev;N. Grau;H. M. Gray;J. A. Gray;E. Graziani;O. G. Grebenyuk;T. Greenshaw;Z. D. Greenwood;K. Gregersen;I. M. Gregor;P. Grenier;J. Griffiths;N. Grigalashvili;A. A. Grillo;S. Grinstein;Y. V. Grishkevich;J.-F. Grivaz;M. Groh;E. Gross;J. Grosse-Knetter;J. Groth-Jensen;K. Grybel;V. J. Guarino;D. Guest;C. Guicheney;A. Guida;S. Guindon;H. Guler;J. Gunther;B. Guo;J. Guo;A. Gupta;Y. Gusakov;V. N. Gushchin;A. Gutierrez;P. Gutierrez;N. Guttman;O. Gutzwiller;C. Guyot;C. Gwenlan;C. B. Gwilliam;A. Haas;S. Haas;C. Haber;H. K. Hadavand;D. R. Hadley;P. Haefner;F. Hahn;S. Haider;Z. Hajduk;H. Hakobyan;D. Hall;J. Haller;K. Hamacher;P. Hamal;M. Hamer;A. Hamilton;S. Hamilton;H. Han;L. Han;K. Hanagaki;K. Hanawa;M. Hance;C. Handel;P. Hanke;J. R. Hansen;J. B. Hansen;J. D. Hansen;P. H. Hansen;P. Hansson;K. Hara;G. A. Hare;T. Harenberg;S. Harkusha;D. Harper;R. D. Harrington;O. M. Harris;K. Harrison;J. Hartert;F. Hartjes;T. Haruyama;A. Harvey;S. Hasegawa;Y. Hasegawa;S. Hassani;M. Hatch;D. Hauff;S. Haug;M. Hauschild;R. Hauser;M. Havranek;B. M. Hawes;C. M. Hawkes;R. J. Hawkings;D. Hawkins;T. Hayakawa;T. Hayashi;D. Hayden;H. S. Hayward;S. J. Haywood;E. Hazen;M. He;S. J. Head;V. Hedberg;L. Heelan;S. Heim;B. Heinemann;S. Heisterkamp;L. Helary;C. Heller;M. Heller;S. Hellman;D. Hellmich;C. Helsens;R. C. W. Henderson;M. Henke;A. Henrichs;A. M. Henriques Correia;S. Henrot-Versille;F. Henry-Couannier;C. Hensel;T. Henß;C. M. Hernandez;Y. Hernández Jiménez;R. Herrberg;A. D. Hershenhorn;G. Herten;R. Hertenberger;L. Hervas;N. P. Hessey;E. Higón-Rodriguez;D. Hill;J. C. Hill;N. Hill;K. H. Hiller;S. Hillert;S. J. Hillier;I. Hinchliffe;E. Hines;M. Hirose;F. Hirsch;D. Hirschbuehl;J. Hobbs;N. Hod;M. C. Hodgkinson;P. Hodgson;A. Hoecker;M. R. Hoeferkamp;J. Hoffman;D. Hoffmann;M. Hohlfeld;M. Holder;S. O. Holmgren;T. Holy;J. L. Holzbauer;Y. Homma;T. M. Hong;L. Hooft van Huysduynen;T. Horazdovsky;C. Horn;S. Horner;J-Y. Hostachy;S. Hou;M. A. Houlden;A. Hoummada;J. Howarth;D. F. Howell;I. Hristova;J. Hrivnac;I. Hruska;T. Hryn’ova;P. J. Hsu;S.-C. Hsu;G. S. Huang;Z. Hubacek;F. Hubaut;F. Huegging;T. B. Huffman;E. W. Hughes;G. Hughes;R. E. Hughes-Jones;M. Huhtinen;P. Hurst;M. Hurwitz;U. Husemann;N. Huseynov;J. Huston;J. Huth;G. Iacobucci;G. Iakovidis;M. Ibbotson;I. Ibragimov;R. Ichimiya;L. Iconomidou-Fayard;J. Idarraga;P. Iengo;O. Igonkina;Y. Ikegami;M. Ikeno;Y. Ilchenko;D. Iliadis;N. Ilic;D. Imbault;M. Imori;T. Ince;J. Inigo-Golfin;P. Ioannou;M. Iodice;A. Irles Quiles;C. Isaksson;A. Ishikawa;M. Ishino;R. Ishmukhametov;C. Issever;S. Istin;A. V. Ivashin;W. Iwanski;H. Iwasaki;J. M. Izen;V. Izzo;B. Jackson;J. N. Jackson;P. Jackson;M. R. Jaekel;V. Jain;K. Jakobs;S. Jakobsen;J. Jakubek;D. K. Jana;E. Jankowski;E. Jansen;H. Jansen;A. Jantsch;M. Janus;G. Jarlskog;L. Jeanty;K. Jelen;I. Jen-La Plante;P. Jenni;A. Jeremie;P. Jež;S. Jézéquel;M. K. Jha;H. Ji;W. Ji;J. Jia;Y. Jiang;M. Jimenez Belenguer;G. Jin;S. Jin;O. Jinnouchi;M. D. Joergensen;D. Joffe;L. G. Johansen;M. Johansen;K. E. Johansson;P. Johansson;S. Johnert;K. A. Johns;K. Jon-And;G. Jones;R. W. L. Jones;T. W. Jones;T. J. Jones;O. Jonsson;C. Joram;P. M. Jorge;J. Joseph;T. Jovin;X. Ju;C. A. Jung;V. Juranek;P. 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Kramarenko;G. Kramberger;M. W. Krasny;A. Krasznahorkay;J. Kraus;J. K. Kraus;A. Kreisel;F. Krejci;J. Kretzschmar;N. Krieger;P. Krieger;K. Kroeninger;H. Kroha;J. Kroll;J. Kroseberg;J. Krstic;U. Kruchonak;H. Krüger;T. Kruker;N. Krumnack;Z. V. Krumshteyn;A. Kruth;T. Kubota;S. Kuehn;A. Kugel;T. Kuhl;D. Kuhn;V. Kukhtin;Y. Kulchitsky;S. Kuleshov;C. Kummer;M. Kuna;N. Kundu;J. Kunkle;A. Kupco;H. Kurashige;M. Kurata;Y. A. Kurochkin;V. Kus;M. Kuze;J. Kvita;R. Kwee;A. Rosa;L. Rotonda;L. Labarga;J. Labbe;S. Lablak;C. Lacasta;F. Lacava;H. Lacker;D. Lacour;V. R. Lacuesta;E. Ladygin;R. Lafaye;B. Laforge;T. Lagouri;S. Lai;E. Laisne;M. Lamanna;C. L. Lampen;W. Lampl;E. Lancon;U. Landgraf;M. P. J. Landon;H. Landsman;J. L. Lane;C. Lange;A. J. Lankford;F. Lanni;K. Lantzsch;S. Laplace;C. Lapoire;J. F. Laporte;T. Lari;A. V. Larionov;A. Larner;C. Lasseur;M. Lassnig;P. Laurelli;W. Lavrijsen;P. Laycock;A. B. Lazarev;O. Dortz;E. Guirriec;C. Maner;E. Menedeu;C. Lebel;T. LeCompte;F. Ledroit-Guillon;H. Lee;J. S. H. Lee;S. C. Lee;L. Lee;M. Lefebvre;M. Legendre;A. Leger;B. C. LeGeyt;F. Legger;C. Leggett;M. Lehmacher;G. Lehmann Miotto;X. Lei;M. A. L. Leite;R. Leitner;D. Lellouch;M. Leltchouk;B. Lemmer;V. Lendermann;K. J. C. Leney;T. Lenz;G. Lenzen;B. Lenzi;K. Leonhardt;S. Leontsinis;C. Leroy;J-R. Lessard;J. Lesser;C. G. Lester;A. Leung Fook Cheong;J. Levêque;D. Levin;L. J. Levinson;M. S. Levitski;A. Lewis;G. H. Lewis;A. M. Leyko;M. Leyton;B. Li;H. Li;S. Li;X. Li;Z. Liang;H. Liao;B. Liberti;P. Lichard;M. Lichtnecker;K. Lie;W. Liebig;R. Lifshitz;C. Limbach;A. Limosani;M. Limper;S. C. Lin;F. Linde;J. T. Linnemann;E. Lipeles;L. Lipinsky;A. Lipniacka;T. M. Liss;D. Lissauer;A. Lister;A. M. Litke;C. Liu;D. Liu;H. Liu;J. B. Liu;M. Liu;S. Liu;Y. Liu;M. Livan;S. S. A. Livermore;A. Lleres;J. Llorente Merino;S. L. Lloyd;E. Lobodzinska;P. Loch;W. S. Lockman;T. Loddenkoetter;F. K. Loebinger;A. Loginov;C. W. Loh;T. Lohse;K. Lohwasser;M. Lokajicek;J. Loken;V. P. Lombardo;R. E. Long;L. Lopes;D. Lopez Mateos;J. Lorenz;M. Losada;P. Loscutoff;F. Lo Sterzo;M. J. Losty;X. Lou;A. Lounis;K. F. Loureiro;J. Love;P. A. Love;A. J. Lowe;F. Lu;H. J. Lubatti;C. Luci;A. Lucotte;A. Ludwig;D. Ludwig;I. Ludwig;J. Ludwig;F. Luehring;G. Luijckx;D. Lumb;L. Luminari;E. Lund;B. Lund-Jensen;B. Lundberg;J. Lundberg;J. Lundquist;M. Lungwitz;G. Lutz;D. Lynn;J. Lys;E. Lytken;H. Ma;L. L. Ma;J. A. Macana Goia;G. Maccarrone;A. Macchiolo;B. Maček;J. Machado Miguens;R. Mackeprang;R. J. Madaras;W. F. Mader;R. Maenner;T. Maeno;P. Mättig;S. Mättig;L. Magnoni;E. Magradze;Y. Mahalalel;K. Mahboubi;G. Mahout;C. Maiani;C. Maidantchik;A. Maio;S. Majewski;Y. Makida;N. Makovec;P. Mal;Pa. Malecki;P. Malecki;V. P. Maleev;F. Malek;U. Mallik;D. Malon;C. Malone;S. Maltezos;V. Malyshev;S. Malyukov;R. Mameghani;J. Mamuzic;A. Manabe;L. Mandelli;I. Mandić;R. Mandrysch;J. Maneira;P. S. Mangeard;I. D. Manjavidze;A. Mann;P. M. Manning;A. Manousakis-Katsikakis;B. Mansoulie;A. Manz;A. Mapelli;L. Mapelli;L. March;J. F. Marchand;F. Marchese;G. Marchiori;M. Marcisovsky;A. Marin;C. P. Marino;F. Marroquim;R. Marshall;Z. Marshall;F. K. Martens;S. Marti-Garcia;A. J. Martin;B. Martin;B. Martin;F. F. Martin;J. P. Martin;Ph. Martin;T. A. Martin;V. J. Martin;B. Ma

A multimodal cell census and atlas of the mammalian primary motor cortex

none258Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input-output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization1-5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.openCallaway, Edward M.; Dong, Hong-Wei; Ecker, Joseph R.; Hawrylycz, Michael J.; Huang, Z. Josh; Lein, Ed S.; Ngai, John; Osten, Pavel; Ren, Bing; Tolias, Andreas Savas; White, Owen; Zeng, Hongkui; Zhuang, Xiaowei; Ascoli, Giorgio A.; Behrens, M. Margarita; Chun, Jerold; Feng, Guoping; Gee, James C.; Ghosh, Satrajit S.; Halchenko, Yaroslav O.; Hertzano, Ronna; Lim, Byung Kook; Martone, Maryann E.; Ng, Lydia; Pachter, Lior; Ropelewski, Alexander J.; Tickle, Timothy L.; Yang, X. William; Zhang, Kun; Bakken, Trygve E.; Berens, Philipp; Daigle, Tanya L.; Harris, Julie A.; Jorstad, Nikolas L.; Kalmbach, Brian E.; Kobak, Dmitry; Li, Yang Eric; Liu, Hanqing; Matho, Katherine S.; Mukamel, Eran A.; Naeemi, Maitham; Scala, Federico; Tan, Pengcheng; Ting, Jonathan T.; Xie, Fangming; Zhang, Meng; Zhang, Zhuzhu; Zhou, Jingtian; Zingg, Brian; Armand, Ethan; Yao, Zizhen; Bertagnolli, Darren; Casper, Tamara; Crichton, Kirsten; Dee, Nick; Diep, Dinh; Ding, Song-Lin; Dong, Weixiu; Dougherty, Elizabeth L.; Fong, Olivia; Goldman, Melissa; Goldy, Jeff; Hodge, Rebecca D.; Hu, Lijuan; Keene, C. Dirk; Krienen, Fenna M.; Kroll, Matthew; Lake, Blue B.; Lathia, Kanan; Linnarsson, Sten; Liu, Christine S.; Macosko, Evan Z.; McCarroll, Steven A.; McMillen, Delissa; Nadaf, Naeem M.; Nguyen, Thuc Nghi; Palmer, Carter R.; Pham, Thanh; Plongthongkum, Nongluk; Reed, Nora M.; Regev, Aviv; Rimorin, Christine; Romanow, William J.; Savoia, Steven; Siletti, Kimberly; Smith, Kimberly; Sulc, Josef; Tasic, Bosiljka; Tieu, Michael; Torkelson, Amy; Tung, Herman; van Velthoven, Cindy T. J.; Vanderburg, Charles R.; Yanny, Anna Marie; Fang, Rongxin; Hou, Xiaomeng; Lucero, Jacinta D.; Osteen, Julia K.; Pinto-Duarte, Antonio; Poirion, Olivier; Preissl, Sebastian; Wang, Xinxin; Aldridge, Andrew I.; Bartlett, Anna; Boggeman, Lara; O’Connor, Carolyn; Castanon, Rosa G.; Chen, Huaming; Fitzpatrick, Conor; Luo, Chongyuan; Nery, Joseph R.; Nunn, Michael; Rivkin, Angeline C.; Tian, Wei; Dominguez, Bertha; Ito-Cole, Tony; Jacobs, Matthew; Jin, Xin; Lee, Cheng-Ta; Lee, Kuo-Fen; Miyazaki, Paula Assakura; Pang, Yan; Rashid, Mohammad; Smith, Jared B.; Vu, Minh; Williams, Elora; Biancalani, Tommaso; Booeshaghi, A. Sina; Crow, Megan; Dudoit, Sandrine; Fischer, Stephan; Gillis, Jesse; Hu, Qiwen; Kharchenko, Peter V.; Niu, Sheng-Yong; Ntranos, Vasilis; Purdom, Elizabeth; Risso, Davide; de Bézieux, Hector Roux; Somasundaram, Saroja; Street, Kelly; Svensson, Valentine; Vaishnav, Eeshit Dhaval; Van den Berge, Koen; Welch, Joshua D.; An, Xu; Bateup, Helen S.; Bowman, Ian; Chance, Rebecca K.; Foster, Nicholas N.; Galbavy, William; Gong, Hui; Gou, Lin; Hatfield, Joshua T.; Hintiryan, Houri; Hirokawa, Karla E.; Kim, Gukhan; Kramer, Daniel J.; Li, Anan; Li, Xiangning; Luo, Qingming; Muñoz-Castañeda, Rodrigo; Stafford, David A.; Feng, Zhao; Jia, Xueyan; Jiang, Shengdian; Jiang, Tao; Kuang, Xiuli; Larsen, Rachael; Lesnar, Phil; Li, Yaoyao; Li, Yuanyuan; Liu, Lijuan; Peng, Hanchuan; Qu, Lei; Ren, Miao; Ruan, Zongcai; Shen, Elise; Song, Yuanyuan; Wakeman, Wayne; Wang, Peng; Wang, Yimin; Wang, Yun; Yin, Lulu; Yuan, Jing; Zhao, Sujun; Zhao, Xuan; Narasimhan, Arun; Palaniswamy, Ramesh; Banerjee, Samik; Ding, Liya; Huilgol, Dhananjay; Huo, Bingxing; Kuo, Hsien-Chi; Laturnus, Sophie; Li, Xu; Mitra, Partha P.; Mizrachi, Judith; Wang, Quanxin; Xie, Peng; Xiong, Feng; Yu, Yang; Eichhorn, Stephen W.; Berg, Jim; Bernabucci, Matteo; Bernaerts, Yves; Cadwell, Cathryn René; Castro, Jesus Ramon; Dalley, Rachel; Hartmanis, Leonard; Horwitz, Gregory D.; Jiang, Xiaolong; Ko, Andrew L.; Miranda, Elanine; Mulherkar, Shalaka; Nicovich, Philip R.; Owen, Scott F.; Sandberg, Rickard; Sorensen, Staci A.; Tan, Zheng Huan; Allen, Shona; Hockemeyer, Dirk; Lee, Angus Y.; Veldman, Matthew B.; Adkins, Ricky S.; Ament, Seth A.; Bravo, Héctor Corrada; Carter, Robert; Chatterjee, Apaala; Colantuoni, Carlo; Crabtree, Jonathan; Creasy, Heather; Felix, Victor; Giglio, Michelle; Herb, Brian R.; Kancherla, Jayaram; Mahurkar, Anup; McCracken, Carrie; Nickel, Lance; Olley, Dustin; Orvis, Joshua; Schor, Michael; Hood, Greg; Dichter, Benjamin; Grauer, Michael; Helba, Brian; Bandrowski, Anita; Barkas, Nikolaos; Carlin, Benjamin; D’Orazi, Florence D.; Degatano, Kylee; Gillespie, Thomas H.; Khajouei, Farzaneh; Konwar, Kishori; Thompson, Carol; Kelly, Kathleen; Mok, Stephanie; Sunkin, SusanCallaway, Edward M.; Dong, Hong-Wei; Ecker, Joseph R.; Hawrylycz, Michael J.; Huang, Z. Josh; Lein, Ed S.; Ngai, John; Osten, Pavel; Ren, Bing; Tolias, Andreas Savas; White, Owen; Zeng, Hongkui; Zhuang, Xiaowei; Ascoli, Giorgio A.; Behrens, M. Margarita; Chun, Jerold; Feng, Guoping; Gee, James C.; Ghosh, Satrajit S.; Halchenko, Yaroslav O.; Hertzano, Ronna; Lim, Byung Kook; Martone, Maryann E.; Ng, Lydia; Pachter, Lior; Ropelewski, Alexander J.; Tickle, Timothy L.; Yang, X. William; Zhang, Kun; Bakken, Trygve E.; Berens, Philipp; Daigle, Tanya L.; Harris, Julie A.; Jorstad, Nikolas L.; Kalmbach, Brian E.; Kobak, Dmitry; Li, Yang Eric; Liu, Hanqing; Matho, Katherine S.; Mukamel, Eran A.; Naeemi, Maitham; Scala, Federico; Tan, Pengcheng; Ting, Jonathan T.; Xie, Fangming; Zhang, Meng; Zhang, Zhuzhu; Zhou, Jingtian; Zingg, Brian; Armand, Ethan; Yao, Zizhen; Bertagnolli, Darren; Casper, Tamara; Crichton, Kirsten; Dee, Nick; Diep, Dinh; Ding, Song-Lin; Dong, Weixiu; Dougherty, Elizabeth L.; Fong, Olivia; Goldman, Melissa; Goldy, Jeff; Hodge, Rebecca D.; Hu, Lijuan; Keene, C. Dirk; Krienen, Fenna M.; Kroll, Matthew; Lake, Blue B.; Lathia, Kanan; Linnarsson, Sten; Liu, Christine S.; Macosko, Evan Z.; Mccarroll, Steven A.; Mcmillen, Delissa; Nadaf, Naeem M.; Nguyen, Thuc Nghi; Palmer, Carter R.; Pham, Thanh; Plongthongkum, Nongluk; Reed, Nora M.; Regev, Aviv; Rimorin, Christine; Romanow, William J.; Savoia, Steven; Siletti, Kimberly; Smith, Kimberly; Sulc, Josef; Tasic, Bosiljka; Tieu, Michael; Torkelson, Amy; Tung, Herman; van Velthoven, Cindy T. J.; Vanderburg, Charles R.; Yanny, Anna Marie; Fang, Rongxin; Hou, Xiaomeng; Lucero, Jacinta D.; Osteen, Julia K.; Pinto-Duarte, Antonio; Poirion, Olivier; Preissl, Sebastian; Wang, Xinxin; Aldridge, Andrew I.; Bartlett, Anna; Boggeman, Lara; O’Connor, Carolyn; Castanon, Rosa G.; Chen, Huaming; Fitzpatrick, Conor; Luo, Chongyuan; Nery, Joseph R.; Nunn, Michael; Rivkin, Angeline C.; Tian, Wei; Dominguez, Bertha; Ito-Cole, Tony; Jacobs, Matthew; Jin, Xin; Lee, Cheng-Ta; Lee, Kuo-Fen; Miyazaki, Paula Assakura; Pang, Yan; Rashid, Mohammad; Smith, Jared B.; Vu, Minh; Williams, Elora; Biancalani, Tommaso; Booeshaghi, A. Sina; Crow, Megan; Dudoit, Sandrine; Fischer, Stephan; Gillis, Jesse; Hu, Qiwen; Kharchenko, Peter V.; Niu, Sheng-Yong; Ntranos, Vasilis; Purdom, Elizabeth; Risso, Davide; de Bézieux, Hector Roux; Somasundaram, Saroja; Street, Kelly; Svensson, Valentine; Vaishnav, Eeshit Dhaval; Van den Berge, Koen; Welch, Joshua D.; An, Xu; Bateup, Helen S.; Bowman, Ian; Chance, Rebecca K.; Foster, Nicholas N.; Galbavy, William; Gong, Hui; Gou, Lin; Hatfield, Joshua T.; Hintiryan, Houri; Hirokawa, Karla E.; Kim, Gukhan; Kramer, Daniel J.; Li, Anan; Li, Xiangning; Luo, Qingming; Muñoz-Castañeda, Rodrigo; Stafford, David A.; Feng, Zhao; Jia, Xueyan; Jiang, Shengdian; Jiang, Tao; Kuang, Xiuli; Larsen, Rachael; Lesnar, Phil; Li, Yaoyao; Li, Yuanyuan; Liu, Lijuan; Peng, Hanchuan; Qu, Lei; Ren, Miao; Ruan, Zongcai; Shen, Elise; Song, Yuanyuan; Wakeman, Wayne; Wang, Peng; Wang, Yimin; Wang, Yun; Yin, Lulu; Yuan, Jing; Zhao, Sujun; Zhao, Xuan; Narasimhan, Arun; Palaniswamy, Ramesh; Banerjee, Samik; Ding, Liya; Huilgol, Dhananjay; Huo, Bingxing; Kuo, Hsien-Chi; Laturnus, Sophie; Li, Xu; Mitra, Partha P.; Mizrachi, Judith; Wang, Quanxin; Xie, Peng; Xiong, Feng; Yu, Yang; Eichhorn, Stephen W.; Berg, Jim; Bernabucci, Matteo; Bernaerts, Yves; Cadwell, Cathryn René; Castro, Jesus Ramon; Dalley, Rachel; Hartmanis, Leonard; Horwitz, Gregory D.; Jiang, Xiaolong; Ko, Andrew L.; Miranda, Elanine; Mulherkar, Shalaka; Nicovich, Philip R.; Owen, Scott F.; Sandberg, Rickard; Sorensen, Staci A.; Tan, Zheng Huan; Allen, Shona; Hockemeyer, Dirk; Lee, Angus Y.; Veldman, Matthew B.; Adkins, Ricky S.; Ament, Seth A.; Bravo, Héctor Corrada; Carter, Robert; Chatterjee, Apaala; Colantuoni, Carlo; Crabtree, Jonathan; Creasy, Heather; Felix, Victor; Giglio, Michelle; Herb, Brian R.; Kancherla, Jayaram; Mahurkar, Anup; Mccracken, Carrie; Nickel, Lance; Olley, Dustin; Orvis, Joshua; Schor, Michael; Hood, Greg; Dichter, Benjamin; Grauer, Michael; Helba, Brian; Bandrowski, Anita; Barkas, Nikolaos; Carlin, Benjamin; D’Orazi, Florence D.; Degatano, Kylee; Gillespie, Thomas H.; Khajouei, Farzaneh; Konwar, Kishori; Thompson, Carol; Kelly, Kathleen; Mok, Stephanie; Sunkin, Susa